MORGANTOWN, W.Va. – For the first time, The Journal of Neuroscience cover on Aug. 7 will feature an image taken from an animated video. The video is hosted on The Journal’s website and was created by a team of researchers from the West Virginia University Center for Neuroscience.
This cover is the first in a series of three that will feature videos from the study “Synaptic Inputs Compete During Rapid Formation of the Calyx of Held: a New Model System for Neural Development,” which was co-authored by researchers from WVU and the University of California – San Diego (UCSD) and led by George A. Spirou, Ph.D., director of the WVU Center for Neuroscience. Paul Holcomb, a neurobiology graduate student in the Spirou lab, is the study’s first author.
The first video shows nanoscale-resolution images from serial block-face scanning electron microscopy (SBEM) of the developing auditory brainstem during the first few days of mouse development. SBEM is new technology that permits visualizing the wiring of the brain in 3D with resolution of several nanometers, or about the size of a protein molecule. One single image volume can require up to 2 TB of computer storage space; new data sets that will each be at least triple this size are currently being collected by Dr. Spirou’s group using the microscopes at UCSD.